Biomed Full Spectrum Hemp Salve
Made with pharmaceutical grade transdermal liposome delivery system.
This topical will help to deliver the medicine through the oil-loving and the water-loving layers of your skin, and designed to treat the specific area you apply it.
5.5 mg THC 2 mg CBD per ml (one pump = 1 ml).
Whole bottle contains 50 ml (275 mg, THC and 100mg, CBD)
The adequate formulation of topical vehicles to treat skin diseases is particularly complex. A desirable formulation should enhance the accumulation of the active drugs in the target tissue (the skin), while avoiding the penetration enhancement to be so large that the drugs reach the systemic circulation in toxic amounts. We have evaluated the transcutaneous penetration of three drugs chosen for their widely variable physicochemical properties: Amphotericin B, Imiquimod and Indole. We incorporated the drugs in fluid or ultra-flexible liposomes. Ultra-flexible liposomes produced enhancement of drug penetration into/through human skin in all cases in comparison with fluid liposomes without detergent, regardless of drug molecular weight. At the same time, our results indicate that liposomes can impede the transcutaneous penetration of molecules, in particular small ones.
Biomed Full Spectrum Hemp Salve contains
Liposomes contain three distinct environments for drugs to dissolve in: the water-lipid interface, the hydrophobic core, and the aqueous interior. As such, they are useful to dissolve/carry hydrophobic, hydrophilic and amphiphilic drugs and antioxidants. This is important since many drugs of therapeutical interest have poor water solubilities and/or form unstable solutions.
In the field of topical vehicles for dermal/transdermal delivery, ultra-flexible liposomes are often considered the vehicle of choice, mainly because of their high performance as transdermal penetration enhancers and their good stability in suspension1,2,3,4,5,6. Ultra-flexible liposomes are composed by a mixture of lipids with low phase transition temperatures and an appropriate amount of a detergent. For more information please go to https://www.nature.com/articles/s41598-018-31693-y